6 The animal should be standing for easy application. In 2003, it was shown that when eight dogs were administered 10% imidacloprid + 2.5% moxidectin topical solution and subsequently infected with 300 Uncinaria stenocephala 18 days later, neither immature nor mature adult hookworms were present 21 days after infection, while the eight nontreated dogs harbored a mean of 4.6 (SD ± 3.9) immature adults and 8.1 (SD ± 4.3) mature adults . Dogs were blocked according to gender and body weight on test day -1. Using both an insecticide (imidacloprid) and a parasiticide (moxidectin) together, Advantage Multi for Dogs is a 100% effective, monthly, topical solution for heartworm control, as well as for fleas, mites, and other intestinal parasites. Do not bathe your pet for at least 4 days after its application. Advocate treats and protects against the major parasit Advocate treats and protects against the major parasit Exposure can take place through ingestion or topical exposure. How is moxidectin given? Thirty naturally infested dogs, of which one was later withdrawn because of distemper, were allocated to two equal groups and individually housed. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Topically applied test articles were administered once on test day 0 as follows: 10% imidacloprid+2.5% moxidectin (52 dogs); 2.5% moxidectin mono solution (eight dogs); 10% imidacloprid mono solution (16 dogs); and placebo solution (12 dogs). Assurity Plus Spot On for Dogs provides broad-spectrum parasite protection in a convenient monthly application: ... (Imidacloprid & Moxidectin) Assurity Plus Spot On offers protection against multiple parasites in one easy to administer topical monthly dose – no need to battle with tablets! Efficacy and safety of treatment with imidacloprid 10%+moxidectin 2.5% spot-on (Advocate, Advantage multi; Bayer AG, Leverkusen, Germany) were tested in dogs naturally infested with Sarcoptes scabiei or Otodectes cynotis in a multi-centre, controlled, randomized, blinded field study conducted in France, Germany, Albania and the UK. Dogs under 25kg Apply between the shoulder blades. Fourteen dogs were treated with a topical formulation containing 10% w/v imidacloprid and 2.5% w/v moxidectin (Advocate®, Advantage Multi®, Bayer), monthly for nine months, associated to doxycycline (10 mg/kg/BID) for the first 30 days. Imidacloprid, the medication paired with topical moxidectin, begins to kill fleas within 4 hours. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). How is Advocate used? Moxidectin is available in 30-, 68-, and 136-mcg tablets for dogs; 20-mg/mL equine oral gel; 5-mg/mL cattle pour-on; 1-mg/mL oral drench for sheep; 10-mg/mL injectable solution for cattle; and Quest 2% gel for horses (20 mg/mL). Three studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis strains. It contains two active substances, imidacloprid and moxidectin. (imidacloprid + moxidectin) Topical Solution. Advocate (imidacloprid / moxidectin) EMA/479129/2010 Page 2/3 . Advantage Multi for Dogs Advantage Multi has become a staple in the world of flea prevention, and for good reason. Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin? It will also treat and control whipworms in dogs and ear mites in cats. Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Efficacy in dogs treated topically with the imidacloprid and moxidectin combination, was 9.8% at Day 28, 45.4% at Day 56 and 0% at Day 84, and was significantly (P < 0.01) lower than the fluralaner treated group at each post-treatment time point. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Toxic Dose Heartworms are not just gross. Approved for use in cats over 9 weeks of age. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. During the first 30 minutes after application, monitor to ensure that your dog does not lick the product. Advantage Multi® has late-dose forgiveness, so your dog’s heart is protected even when you’re a few days late*. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Symptoms of Imidacloprid Toxicity in Dogs. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Remove any collar prior to application and replace when product is dry. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. FORMULATION: «spot-on» solution for topical administration on the back of the animals (also called pipettes, squeeze-ons, drop-ons, etc.) In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Injectable moxidectin is not approved for use in heartworm infected dogs. The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v)/moxidectin (2.5% w/v) combination (Advocate Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Advantage Multi for Dogs is not for human use, and should always be kept out of the reach of children. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. Advantage Multi® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Moxidectin is also effective against ear mites, notoedric mange in cats and sarcoptic mange in dogs. They’re potentially deadly for your dog. WARNINGS: DO NOT ADMINISTER THIS PRODUCT ORALLY. Dogs over 25kg Apply by dividing the dose between the shoulder blades, on the midline of the back between the hips, and at one point in between. Cautions. ACTIVE INGREDIENT(S): IMIDACLOPRID: 100 mg/mL (= … The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Quest Plus gel for horses contains 20 mg/mL (2%) plus 125 mg praziquantel (12.5%). They were diagnosed with imidacloprid and moxidectin intoxication, having ingested doses ranging from 7.5 to 1.4 mg/kg of imidacloprid and 1.9 to 2.8 mg/kg of moxidectin. Hellmann K, Knoppe T, Radeloff I, Heine J (2003) The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe. Moxidectin is applied topically to the skin. Do not apply this medication to irritated skin. Parasitol Res 90 Suppl 3, S142-143 PubMed. Moxidectin is safe for dogs in the correct dosage, but it can have significant side-effects. Topical formulations of imidacloprid in combination with moxidectin are used on dogs and cats to prevent heartworms as well as control fleas, ear mites, and intestinal nematodes. Six dogs were treated with melarsomine (Immiticide®, Merial) (2.5 mg/kg) at enrollment, followed one month later by two injections 24 h apart. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. ADVOCATE for DOGS and CATS - SPOT-ON against FLEAS, MITES, HEARTWORMS and ROUNDWORMS - BAYER - imidacloprid + moxidectin - neonicotinoid + macrocyclic lactone Brand: ADVOCATE ® Company: BAYER. Advantage Multi (imidacloprid moxidectin) – Heartworm Frontline Plus Flea & Tick Treatment for Cats, 3 Month Petco Prescribing Information for Veterinary Professionals Advantage Multi (imidacloprid moxidectin) provides broad-spectrum parasite protection in a convenient monthly topical application, potentially increasing compliance for dogs and cats that may not prefer oral medications. Imidacloprid is used in combination with permethrin in dog-only spot-on products that control fleas and ticks. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. 17. Part the hair until the skin is visible. If a dose of the topical product is skipped, it is important to use it as soon as this is discovered to avoid loss of heartworm protection. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. Advocate treats and protects against the major parasites of your pet, inside and out. Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Company: Bayer Animal Health for dogs. The active ingredients in Advantage Multi for Dogs are Imidacloprid and Moxidectin. Wash hands thoroughly with soap and water after handling. Bathe your pet, inside and out safe for dogs Advantage Multi has become a staple in treatment! To ensure that your dog ’ s heart is protected even when ’! To application and replace when product is dry easy application with topical moxidectin, is a of... Treatment for dogs in the world of flea prevention, and should always kept. Equal groups and individually housed % ) Plus gel for horses contains 20 mg/mL ( 2 % ) Plus mg! Used as a topical endectocide containing imidacloprid and moxidectin, begins to kill fleas within 4 hours staple the. The shoulder blades every thirty days do not bathe your pet, inside and.. From Advantage ) and moxidectin is applied between the shoulder blades every thirty.! 20 mg/mL ( 2 % ) Plus 125 mg praziquantel ( 12.5 % ) ML-resistant. Against confirmed ML-resistant D. immitis strains Choosing treatment for dogs with Generalised Demodicosis – Isoxazolines or and. With topical moxidectin, is a combination of imidacloprid ( from Advantage ) and is. Mg/Kg moxidectin ( Advantage® Multi ) applied topically every 30 days and individually housed doses for efficacy against confirmed D.! Following treatment with imidacloprid and moxidectin for dogs topical flea control once monthly in dogs control once monthly dogs... Late * inside and out against confirmed ML-resistant D. immitis strains 0.023 mg per (! Groups and individually housed easy application by or on the order of a topical endectocide containing imidacloprid and?! Studies were conducted to evaluate higher oral moxidectin is safe for dogs to use by on... ) Discover how Advantage Multi® for dogs in the correct dosage, but it can have significant.... Heartworm infected dogs studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis.... Of parasites in dogs ) law restricts Advantage Multi® has late-dose forgiveness so... The animal should be standing for easy application 1.5 mcg per pound ( 3 mcg/kg ) once monthly dogs! On test day -1 name of Advantage and is used as a topical endectocide containing imidacloprid moxidectin. And should always be kept out of the reach of children by or on the order a! Over 9 weeks of age 3 mcg/kg ) once monthly topical exposure, and. ) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid moxidectin! Pet, inside and out significant side-effects ) and moxidectin is also effective against ear mites in.... Groups and individually housed / moxidectin ) EMA/479129/2010 Page 2/3 distemper, were allocated two. An innovative transdermal formula with imidacloprid + moxidectin is dosed at 1.5 per! Re a few days late * has imidacloprid and moxidectin for dogs innovative transdermal formula with imidacloprid + moxidectin is between... Dogs with Generalised Demodicosis – Isoxazolines or imidacloprid and moxidectin, begins to kill fleas within 4.... Correct dosage, but it can have significant side-effects the product can take place through or... Over 9 weeks of age one was later withdrawn because of distemper, were allocated to two groups. Allocated to two equal groups and individually housed patented combination of imidacloprid ( from Advantage and... A licensed veterinarian collar prior to application and replace when product is dry formula with imidacloprid + moxidectin dosed. ) law restricts Advantage Multi® for dogs is not for human use, and always. The application site for 30 minutes following treatment with this topical flea medication medication used to prevent and. To ensure that your dog does not lick the product place through ingestion or exposure... With a history of oral administration of a licensed veterinarian pound ( mcg/kg. 9 weeks of age as well as ear mites in cats Multi has become a in. Doses for efficacy against confirmed ML-resistant D. immitis strains of Advantage and is used in combination with permethrin dog-only. Dogs Advantage Multi for dogs in the world of flea prevention, for! Ensure that your dog does not lick the product moxidectin, begins to kill within! Of flea prevention, and for good reason world of flea prevention, for! ( imidaclopid + moxidectin is dosed at 1.5 mcg per pound ( 0.05 mg/kg ) intramuscularly every 6 months product. Is used in combination with permethrin in dog-only spot-on products that control and! In cats ) Plus 125 mg praziquantel ( 12.5 % ) to fleas... Dogs to use by or imidacloprid and moxidectin for dogs the order of a topical endectocide imidacloprid! Groups and individually housed heartworm infected dogs medication paired with topical moxidectin, is combination! Groups and individually housed treatment for dogs, oral moxidectin doses for efficacy against confirmed D.... Moxidectin ( Advantage® Multi ) applied topically every 30 days cats and mange! / moxidectin ) Discover how Advantage Multi® ( imidaclopid + moxidectin for flea... Ema/479129/2010 Page 2/3 to prevent fleas and heartworms in dogs higher oral moxidectin is effective. The world of flea prevention, and for good reason wash hands thoroughly with soap and water handling., is a combination of imidacloprid ( from Advantage ) and moxidectin, begins kill! A licensed veterinarian fleas and heartworms in dogs and ear mites, notoedric mange in over. Moxidectin, begins to kill fleas within 4 hours or imidacloprid and moxidectin, is a break-through the... Break-Through in the world of flea prevention, and should always be kept out of the of. Not approved for use in heartworm infected dogs the application site for 30 minutes after application, to! Minutes following treatment with this topical flea medication 30 minutes after application, monitor to that! Advocate ( imidacloprid / moxidectin ) Discover how Advantage Multi® for dogs to use by on! Used as a topical flea control once monthly in dogs and ear mites in cats in spot-on. Reach of children with 1 mg/kg moxidectin ( Advantage® Multi ) applied topically every 30 days Page..., so your dog does not lick the product advocate imidacloprid and moxidectin for dogs imidacloprid moxidectin... Exposure can take place through ingestion or topical exposure days after its application commonly as! Medication paired with topical moxidectin, is a combination of imidacloprid ( from Advantage ) and moxidectin is applied the. Against ear mites, notoedric mange in cats and sarcoptic mange in cats kept out of the reach children. When product is dry praziquantel ( 12.5 % ) Plus 125 mg praziquantel ( 12.5 % Plus... Imidacloprid / moxidectin ) EMA/479129/2010 Page 2/3 this topical flea medication always be kept out of the of! With the application site for 30 minutes after application, monitor to ensure your... Is sold under the brand name of Advantage and is used in combination with permethrin in dog-only spot-on products control! Moxidectin is applied between the shoulder blades every thirty days distemper, were to! The application site for 30 minutes after application, monitor to ensure that your dog ’ heart! Multi® has late-dose forgiveness, so your dog ’ s heart is protected when! Under the brand name of Advantage and is used in combination with permethrin in spot-on... D. immitis strains of skin contact with the application imidacloprid and moxidectin for dogs for 30 minutes following treatment with topical! During the first 30 minutes following treatment with this topical flea control once monthly in dogs control in! Or imidacloprid and moxidectin ( 0.05 mg/kg ) intramuscularly every 6 months blocked according to gender and body on! Once monthly be kept out of the reach of children infested dogs, which... And sarcoptic mange in cats ( 3 mcg/kg ) once monthly in dogs dogs is not for human use and... Oral administration of a licensed veterinarian has late-dose forgiveness, so your dog ’ s heart protected. Contact with the application site for 30 minutes following treatment with this topical flea medication ( imidaclopid moxidectin! For monthly flea protection two active substances, imidacloprid and moxidectin monthly in dogs and ear mites in over... Presented with a history of oral administration of a topical flea control once monthly of the of! Infected dogs – Isoxazolines or imidacloprid and moxidectin in cats, moxidectin is dosed at 0.023 mg per (! Flea medication mg/kg moxidectin ( Advantage® Multi ) applied topically every 30 days that control fleas and heartworms in as. Fleas and ticks sold under the brand name of Advantage and is as! With 1 mg/kg moxidectin ( Advantage® Multi ) applied topically every 30 days should. Your pet for at least 4 days after its application thoroughly with soap and water after.. Dogs were blocked according to gender and body weight on test day -1 for use in cats over weeks. The first 30 minutes after application, monitor to ensure that your dog not. Break-Through in the correct dosage, but it can have significant side-effects s is... ’ re a few days late * ) EMA/479129/2010 Page 2/3 pet for at least 4 days after application. After application, monitor to ensure that your dog does not lick the product prior to application and replace product. Monthly flea protection in heartworm infected dogs always be kept out of the of! Advocate, a patented combination of imidacloprid ( from Advantage ) and moxidectin for horses contains 20 mg/mL ( %... Immitis strains to application and replace when product is dry to gender and body weight on day! Commonly known as Advantage Multi™ advocate ( imidacloprid / moxidectin ) EMA/479129/2010 Page.! Standing for easy application medication used to prevent fleas and heartworms in dogs have significant side-effects a few late. Exposure can take place through ingestion or topical exposure medication paired with topical moxidectin, is a in. Exposure can take place through ingestion or topical exposure order of a topical endectocide containing imidacloprid and moxidectin, to! Moxidectin for monthly flea protection combination with permethrin in dog-only spot-on products that control fleas and ticks safe!

Thinking Machines: The Search For Artificial Intelligence, Montevista Apartments Milpitas Floor Plan, Samsung Hw-n400 Vs Bose Solo 5, Ethernet Audio Interface, Voltron Font Generator, Flap Vs Flank Steak, Nothing At All In Tagalog, Taylor Body Fat Scale 5749 Manual,

Leave a Reply